Pesticide composition comprising propamocarb-fosetylate and an insecticidally active substance

ABSTRACT

The present invention relates to a pesticide composition intended for protecting plants, crops or seeds against phyto-pathogenic fungi or damaging insects, and the corresponding methods of treatment using the said composition. More precisely, the subject of the present invention is a pesticide composition based on propamocarb-fosetylate, an insecticide active substance and optionally a further fungicide active substance.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a Divisional of U.S. patent application Ser. No.12/520,808 filed Jun. 22, 2009, which is a §371 National StageApplication of PCT/EP2007/064424 filed Dec. 21, 2007, which claimspriority to EP 06127172.2 filed Dec. 22, 2006, the entire contents ofeach are herein incorporated by reference in their entireties.

BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates to a pesticide composition intended forprotecting plants, crops or seeds against fungal diseases or insectdamages, and the corresponding methods of protection by application ofthe said composition. More precisely, the subject of the presentinvention is a pesticide composition based on propamocarb-fosetylate andan insecticide active substance or compound and optionally a furtherfungicide active substance or compound.

2. Description of Related Art

As regards pesticide activity, in particular for the protection ofcrops, one of the problems at the heart of the research studies carriedout in this technical field is the improvement of performances, inparticular in terms of biological activity and in particular in terms ofmaintaining such an activity over time.

SUMMARY OF THE INVENTION

The present invention provides a pesticide composition which can beused, in particular by the farmer, for controlling the pest infestingcrops and in particular for controlling insects or diseases of corn,beet, cotton, canola, beans, peanuts vegetables, lucerne, soybean,market garden crops, turf, wood, tree and horticultural plants, forexample Pythium on corn. The pesticide compounds useful for theprotection of plants must be endowed with an ecotoxicity which isreduced to the minimum. As far as possible, they should not be dangerousor toxic to the operator during use. The economic factor should ofcourse not be overlooked in the search for novel pesticide agents.

Propamocarb-fosetylate is a known compound having as chemical namedimethyl-[3-(propoxycarbonylamino)propyl]ammonium-O-ethylphosphonate andwhich is represented by the following formula:

This compound is described in international patent applicationWO-99/42468. Some fungicide activity is reported with regard to thestraight use of this compound to control Plasmopara viticola.

Some mixtures with other fungicide active substances are mentioned.However, this document is silent with regard to any results orbiological activity of such potential mixtures. In particular, thisdocument does not report any activity to specifically control seeddiseases with propamocarb-fosetylate mixtures nor this documentdiscloses any mixture of propamocarb-fosetylate with any insecticideactive substance. There is also no mention in this document of anyparticular result or biological activity of any mixture ofpropamocarb-fosetylate with an insecticide active substance.

In international patent application WO-2007/101547 there are genericallydisclosed numerous mixtures of some phtalamide insecticide compoundswith known fungicide substances. The association of these insecticidecompounds with propamocarb-fosetylate has not been specificallydisclosed nor has been subject to any experimentation. Such anassociation does not form part of the present invention.

In a main aspect, the present invention provides a compositioncomprising:

-   -   A) propamocarb-fosetylate and    -   B) an insecticide compound        in an A/B weight ratio ranging from 1/1,000 to 1,000/1; provided        that insecticide compound B differs from compounds of formula        (I)

wherein:

-   -   Hal represents a chlorine atom, a bromine atom or a iodine atom;    -   R represents hydrogen or methyl and * may represent a carbon        atom in R- or S-configuration.

The present invention advantageously provides a pesticide compositionwhich is completely high-performing in particular as regards itsefficacy against pests and the perenniallity of this efficacy so as tobe able to reduce the doses of chemical products spread in theenvironment for combating pest damages or attacks of plants or crops.

The invention provides a pesticide composition capable to be more activeand active for longer, and which therefore has a lower dose, but whichis also less toxic, in particular in the treatment of plants andparticularly the foliar and seed treatments of fungal diseases or thecontrol of insects, for example, of cereals, cotton, peanut, bean, beet,canola, Solanaceae, grapevine, vegetables, lucerne, soybean, marketgarden crops, turf, wood or horticultural plants.

The composition according to the invention allows controlling a broadvariety of insects or fungi. For example, the pesticide compositionaccording to the invention exhibits an improved efficacy against funguslike Plasmodiophoromycetes, Oomycetes, Chytridiomycetes, Zygomycetes,Basidiomycetes, Deuteromycetes and Ascomycetes.

All these objectives or advantages, among others, were achieved byfinding a pesticide composition comprising propamocarb-fosetylate; aninsecticide compound and optionally a further fungicide compound. Such acomposition surprisingly and unexpectedly allows a very high andperennial insecticide or anti-fungal efficacy against a broad spectrumof insects or fungi and in particular against those responsible fordiseases or damages of corn for example to Oomycetes. Other insect pestsor diseases of corn can be controlled with the pesticide compositionaccording to the invention, in particular the control of Ascomycetes orBasidiomycetes.

The pesticide composition according to the invention may also be usedfor the treatment of bacterial or virus diseases.

Insects or nematodes that can be controlled with the pesticidecomposition according to the invention include a broad variety of thesedamaging organisms.

DETAILED DESCRIPTION OF A PREFERRED EMBODIMENT

For the composition according to the invention, insecticide compound Bis preferably selected in the list consisting of:

-   -   B1) a compound capable to act as an acetylcholine receptor        agonist or antagonist, for example a compound of the type        chloronicotinyl like acetamiprid, clothianidin, dinotefuran,        imidacloprid, imidaclothiz also known as        (2E)-1-[(2-chloro-1,3-thiazol-5-yl)methyl]-N-nitroimidazolidin-2-imine,        nitenpyram, nithiazine, thiacloprid; thiamethoxam; nicotine,        bensultap, cartap,        (2E)-1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3,5-dimethyl-N-nitro-1,3,5-triazinan-2-imine;    -   B2) a compound capable to inhibit acetylcholinesterase (ACHE),        for example a compound of the type carbamate like alanycarb,        aldicarb, aldoxycarb, allyxycarb, aminocarb, bendiocarb,        benfuracarb, bufencarb, butacarb, butocarboxim, butoxycarboxim,        carbaryl, carbofuran, carbosulfan, cloethocarb, dimetilan,        ethiofencarb, fenobucarb, fenothiocarb, formetanate,        furathiocarb, isoprocarb, metam-sodium, methiocarb, methomyl,        metolcarb, oxamyl, pirimicarb, promecarb, propoxur, thiodicarb,        thiofanox, trimethacarb, XMC, xylylcarb; triazamate; a compound        of the type organophosphate like acephate, azamethiphos,        azinphos (-methyl, -ethyl), bromophos-ethyl, bromfenvinfos        (-methyl), butathiofos, cadusafos, carbophenothion,        chlorethoxyfos, chlorfenvinphos, chlormephos, chlorpyrifos        (-methyl/-ethyl), coumaphos, cyanofenphos, cyanophos,        chlorfenvinphos, demeton-s-methyl, demeton-s-methylsulphon,        dialifos, diazinon, dichlofenthion, dichlorvos/ddvp,        dicrotophos, dimethoate, dimethylvinphos, dioxabenzofos,        disulfoton, epn, ethion, ethoprophos, etrimfos, famphur,        fenamiphos, fenitrothion, fensulfothion, fenthion, flupyrazofos,        fonofos, formothion, fosmethilan, fosthiazate, heptenophos,        iodofenphos, iprobenfos, isazofos, isofenphos, isopropyl        o-salicylate, isoxathion, malathion, mecarbam, methacrifos,        methamidophos, methidathion, mevinphos, monocrotophos, naled,        omethoate, oxydemeton-methyl, parathion (-methyl/-ethyl),        phenthoate, phorate, phosalone, phosmet, phosphamidon,        phosphocarb, phoxim, pirimiphos (-methyl/-ethyl), profenofos,        propaphos, propetamphos, prothiofos, prothoate, pyraclofos,        pyridaphenthion, pyridathion, quinalphos, sebufos, sulfotep,        sulprofos, tebupirimfos, temephos, terbufos, tetrachlorvinphos,        thiometon, triazophos, triclorfon, vamidothion;    -   B3) a compound capable to modulate the sodium channel or to        block the voltage dependant sodium channel, for example a        compound of the type pyrethroid like acrinathrin, allethrin        (d-cis-trans, d-trans), beta-cyfluthrin, bifenthrin,        bioallethrin, bioallethrin-s-cyclopentyl-isomer,        bioethanomethrin, biopermethrin, bioresmethrin, chlovaporthrin,        cis-cypermethrin, cis-resmethrin, cis-permethrin, clocythrin,        cycloprothrin, cyfluthrin, cyhalothrin, cypermethrin (alpha,        beta-, theta-, zeta-), cyphenothrin, deltamethrin, empenthrin        (1R-isomer), esfenvalerate, etofenprox, fenfluthrin,        fenpropathrin, fenpyrithrin, fenvalerate, flubrocythrinate,        flucythrinate, flufenprox, flumethrin, fluvalinate, fubfenprox,        gamma-cyhalothrin, imiprothrin, kadethrin, lambda-cyhalothrin,        metofluthrin, permethrin (cis-, trans-), phenothrin (1r-trans        isomer), prallethrin, profluthrin, protrifenbute, pyresmethrin,        resmethrin, RU15525, silafluofen, tau-fluvalinate, tefluthrin,        terallethrin, tetramethrin (−1r-isomer), tralomethrin,        transfluthrin, ZXI8901, pyrethrins (pyrethrum); for example DDT;        for example a compound of the type oxadiazine like indoxacarb;    -   B4) a compound capable to modulate acetylcholine receptor, for        example a compound of the type spinosyn like spinosad;    -   B5) a compound capable to act as GABA-gated chloride channel        antagonist, for example a compound of the type cyclodiene        organochlorine like camphechlor, chlordane, endosulfan,        gamma-HCH, HCH, heptachlor, lindane, methoxychlor; a compound of        the type fiprole like acetoprole, ethiprole, fipronil,        vaniliprole;    -   B6) a compound capable to activate the chloride channel, for        example a compound of the type mectin like avermectin,        emamectin, emamectin-benzoate, ivermectin, milbemycin;    -   B7) a compound capable to mimic a juvenile hormone like        diofenolan, epofenonane, fenoxycarb, hydroprene, kinoprene,        methoprene, pyriproxifen, triprene;    -   B8) a compound capable to act as an ecdysone agonist or        disruptor, for example a compound of the type diacylhydrazine        like chromafenozide, halofenozide, methoxyfenozide,        tebufenozide;    -   B9) a compound capable to inhibit chitin biosynthesis, for        example a compound of the type benzoylurea like bistrifluoron,        chlofluazuron, diflubenzuron, fluazuron, flucycloxuron,        flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron,        penfluoron, teflubenzuron, triflumuron; buprofezin; cyromazine;    -   B10) a compound capable to inhibit oxidative phosphorylation or        to disrupt ATP, like diafenthiuron; for example a compound of        the type organotin like azocyclotin, cyhexatin,        fenbutatin-oxide;    -   B11) a compound capable to uncouple oxidative phosphorylation        via disruption of H proton gradient, for example a compound of        the type pyrrole like chlorfenapyr; a compound of the type        dinitrophenole like binapacyrl, dinobuton, dinocap, DNOC;    -   B12) a compound capable to inhibit site I electron transport,        for example a compound of the type METI like fenazaquin,        fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad,        tolfenpyrad; hydramethylnon; dicofol;    -   B13) a compound capable to inhibit site II electron transport        like rotenone;    -   B14) a compound capable to inhibit site III electron transport        like acequinocyl, fluacrypyrim;    -   B15) a compound capable to act as a microbial disruptor of        insect midgut or intestinal membrane like stains of Bacillus        thuringiensis;    -   B16) a compound capable to inhibit lipid synthesis, for example        a compound of the type tetronic acid insecticide like        spirodiclofen, spiromesifen or a compound of the type tetramic        acid insecticide like spirotetramat also known as carbonic acid        cis-3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en-4-yl        ethyl ester (CAS-reg-no 203313-25-1) and        3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en-4-yl        ethyl carbonate also known as carbonic acid        3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en-4-yl        ethyl ester (CAS-reg-no 382608-10-8);    -   B17) a compound of the type carboxamide like flonicamid;    -   B18) a compound capable to act as an octopaminergic agonist like        amitraz;    -   B19) a compound capable to inhibit magnesium-stimulated ATP-ase        like propargite;    -   B20) a compound of the type BDCA or capable to act as a ryanodin        receptor agonist like rynaxypyr or phthalamides, e.g.        flubendiamide also known as        N2-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N1-[2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]-1,2-benzenedicarboxamide        (CAS-reg-no 272451-65-7);    -   B21) a compound of the type nereistoxin analogue insecticide        like thiocyclam hydrogen oxalate, thiosultap-sodium;    -   B22) a compound of the types biologica, hormones or pheromones        like azadirachtin, Bacillus spec., Beauveria spec., codlemone,        Metarrhizium spec., Paecilomyces spec., thuringiensin,        Verticillium spec.;    -   B23) a compound of unknown or non-specific mode of action, for        example a compound of the type fumigant like aluminium        phosphide, methyl bromide, sulfuryl fluoride; a compound of the        type selective feeding blocker like cryolite, flonicamid,        pymetrozine; a compound of the type mite growth inhibitor like        clofentezine, etoxazole, hexythiazox; amidoflumet, benclothiaz,        benzoximate, bifenazate, bromopropylate, buprofezin,        chinomethionat, chlordimeform, chloro-benzilate, chloropicrin,        clothiazoben, cycloprene, cyflumetofen, dicyclanil, fenoxacrim,        fentrifanil, flubendiamide, flubenzimine, flufenerim, flutenzin,        gossyplure, hydramethylnone, japonilure, metoxadiazone,        petroleum, piperonyl butoxide, potassium oleate, pyrafluprole,        pyridalyl, pyriprole, sulfluramid, tetradifon, tetrasul,        triarathene, verbutin.

More preferably, the composition according to the invention comprisespropamocarb-fosetylate and abamectin; propamocarb-fosetylate andacephate; propamocarb-fosetylate and acetamiprid; propamocarb-fosetylateand acrinathrin; propamocarb-fosetylate and aldicarb;propamocarb-fosetylate and alpha-cypermethrin; propamocarb-fosetylateand beta-cyfluthrin; propamocarb-fosetylate and bifenthrin;propamocarb-fosetylate and carbaryl; propamocarb-fosetylate andcarbofuran; propamocarb-fosetylate and chlorfenapyr;propamocarb-fosetylate and chlorfluazuron; propamocarb-fosetylate andchlorpyrifos-E; propamocarb-fosetylate and clothianidin;propamocarb-fosetylate and cyfluthrin; propamocarb-fosetylate andcypermethrin; propamocarb-fosetylate and cyromazine;propamocarb-fosetylate and deltamethrin; propamocarb-fosetylate anddiflubenzuron; propamocarb-fosetylate and dinotefuran;propamocarb-fosetylate and emamectin-benzoate; propamocarb-fosetylateand ethiprole; propamocarb-fosetylate and fenpyroximate;propamocarb-fosetylate and fipronil; propamocarb-fosetylate andflonicamid; propamocarb-fosetylate and flubendiamide;propamocarb-fosetylate and flufenoxuron; propamocarb-fosetylate andgamma-cyhalothrin; propamocarb-fosetylate and hexaflumuron;propamocarb-fosetylate and imidacloprid; propamocarb-fosetylate andindoxacarb; propamocarb-fosetylate and L-cyhalothrin;propamocarb-fosetylate and lepimectin; propamocarb-fosetylate andlufenuron; propamocarb-fosetylate and methamidophos;propamocarb-fosetylate and methiocarb; propamocarb-fosetylate andmethomyl; propamocarb-fosetylate and methoxyfenozide;propamocarb-fosetylate and milbemycin; propamocarb-fosetylate andnitenpyram; propamocarb-fosetylate and novaluron; propamocarb-fosetylateand profenofos; propamocarb-fosetylate and pymetrozine;propamocarb-fosetylate and rynaxapyr; propamocarb-fosetylate andspinosad; propamocarb-fosetylate and spirodiclofen;propamocarb-fosetylate and spiromesifen; propamocarb-fosetylate andspirotetramate; propamocarb-fosetylate and tebufenozide;propamocarb-fosetylate and tebufenozide; propamocarb-fosetylate andtebufenpyrad; propamocarb-fosetylate and tebufenpyrad;propamocarb-fosetylate and tebupirimphos; propamocarb-fosetylate andteflubenzuron; propamocarb-fosetylate and tefluthrin;propamocarb-fosetylate and thiacloprid; propamocarb-fosetylate andthiamethoxam; propamocarb-fosetylate and thiodicarb;propamocarb-fosetylate and triazophos triflumuron;propamocarb-fosetylate and imidaclothiz; propamocarb-fosetylate and(2E)-1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3,5-dimethyl-N-nitro-1,3,5-triazinan-2-imine.

Even more preferably, the composition according to the inventioncomprises propamocarb-fosetylate and abamectin; propamocarb-fosetylateand acetamiprid; propamocarb-fosetylate and aldicarb;propamocarb-fosetylate and beta-cyfluthrin; propamocarb-fosetylate andcarbofuran; propamocarb-fosetylate and chlorpyrifos-E;propamocarb-fosetylate and clothianidin; propamocarb-fosetylate andcypermethrin; propamocarb-fosetylate and cyromazine;propamocarb-fosetylate and deltamethrin; propamocarb-fosetylate anddiflubenzuron; propamocarb-fosetylate and emamectin-benzoate;propamocarb-fosetylate and ethiprole; propamocarb-fosetylate andfipronil; propamocarb-fosetylate and gamma-cyhalothrin;propamocarb-fosetylate and imidacloprid; propamocarb-fosetylate andL-cyhalothrin; propamocarb-fosetylate and lufenuron;propamocarb-fosetylate and methiocarb; propamocarb-fosetylate andmethoxyfenozide; propamocarb-fosetylate and pymetrozine;propamocarb-fosetylate and rynaxapyr; propamocarb-fosetylate andspinosad; propamocarb-fosetylate and spirodiclofen;propamocarb-fosetylate and spiromesifen; propamocarb-fosetylate andspirotetramate; propamocarb-fosetylate and tebufenozide;propamocarb-fosetylate and tebufenpyrad; propamocarb-fosetylate andtefluthrin; propamocarb-fosetylate and thiacloprid;propamocarb-fosetylate and thiamethoxam; propamocarb-fosetylate andthiodicarb; propamocarb-fosetylate and triflumuron;propamocarb-fosetylate and imidaclothiz; preferred composition accordingto the invention comprises propamocarb-fosetylate and(2E)-1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3,5-dimethyl-N-nitro-1,3,5-triazinan-2-imine.

Still even more preferably, the composition according to the inventioncomprises propamocarb-fosetylate and abamectin; propamocarb-fosetylateand aldicarb; propamocarb-fosetylate and beta-cyfluthrin;propamocarb-fosetylate and chlorpyrifos-E; propamocarb-fosetylate andclothianidin; propamocarb-fosetylate and cyromazine;propamocarb-fosetylate and deltamethrin; propamocarb-fosetylate anddiflubenzuron; propamocarb-fosetylate and emamectin-benzoate;propamocarb-fosetylate and fipronil; propamocarb-fosetylate andgamma-cyhalothrin; propamocarb-fosetylate and imidacloprid;propamocarb-fosetylate and L-cyhalothrin; propamocarb-fosetylate andmethiocarb; propamocarb-fosetylate and pymetrozine;propamocarb-fosetylate and rynaxapyr; propamocarb-fosetylate andspinosad; propamocarb-fosetylate and spirodiclofen;propamocarb-fosetylate and spiromesifen; propamocarb-fosetylate andspirotetramate; propamocarb-fosetylate and tebufenozide;propamocarb-fosetylate and tebufenpyrad; propamocarb-fosetylate andtefluthrin; propamocarb-fosetylate and thiamethoxam;propamocarb-fosetylate and thiodicarb; propamocarb-fosetylate andimidaclothiz; propamocarb-fosetylate and(2E)-1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3,5-dimethyl-N-nitro-1,3,5-triazinan-2-imine.

For the composition according to the invention the A/B weight ratiopreferably ranges from 1/125 to 125/1; more preferably from 1/25 to25/1.

According to another aspect of the present invention, in the pesticidecomposition according to the invention, the compound ratio A/B can beadvantageously selected so as to produce a synergistic effect. The termsynergistic effect is understood to mean in particular that defined byColby in an article entitled “Calculation of the synergistic andantagonistic responses of herbicide combinations” Weeds, (1967), 15,pages 20-22.

The latter article mentions the formula:

$E = {X + Y - \frac{XY}{100}}$

wherein E represents the expected percentage of inhibition of the pestfor the combination of the two compounds at defined doses (for exampleequal to x and y respectively), X is the percentage of inhibitionobserved for the pest by compound A at a defined dose (equal to x), Y isthe percentage of inhibition observed for the pest by compound B at adefined dose (equal to y). When the percentage of inhibition observedfor the combination is greater than E, there is a synergistic effect.

The term “synergistic effect” also means the effect defined byapplication of the Tammes method, “Isoboles, a graphic representation ofsynergism in pesticides”, Netherlands Journal of Plant Pathology, 70(1964), pages 73-80.

In a further aspect, the present invention provides a compositioncomprising:

-   -   A) propamocarb-fosetylate;    -   B) an insecticide compound and    -   C) a further fungicide compound in an A/B/C weight ratio ranging        from 1/1,000/1,000 to 1/0.001/0.001; provided that insecticide        compound B differs from compounds of formula (I)

wherein:

-   -   Hal represents a chlorine atom, a bromine atom or a iodine atom;    -   * represents a carbon atom in R- or S-configuration.

In addition to propamocarb-fosetylate and an insecticide compound B asherein-defined, the composition according to the invention can comprisea further fungicide compound C preferably selected in the listconsisting of:

-   -   C1) a compound capable to inhibit the nucleic acid synthesis        like benalaxyl, benalaxyl-M, bupirimate, clozylacon,        dimethirimol, ethirimol, furalaxyl, hymexazol, mefenoxam,        metalaxyl, metalaxyl-M, ofurace, oxadixyl, oxolinic acid;    -   C2) a compound capable to inhibit the mitosis and cell division        like benomyl, carbendazim, diethofencarb, ethaboxam,        fuberidazole, pencycuron, thiabendazole, thiophanate-methyl,        zoxamide;    -   C3) a compound capable to inhibit the respiration for example    -   as CI-respiration inhibitor like diflumetorim;    -   as CII-respiration inhibitor like boscalid, carboxin, fenfuram,        flutolanil, furametpyr, furmecyclox, mepronil, oxycarboxin,        penthiopyrad, thifluzamide;    -   as CIII-respiration inhibitor like amisulbrom, azoxystrobin,        cyazofamid, dimoxystrobin, enestrobin, famoxadone, fenamidone,        fluoxastrobin, kresoxim-methyl, metominostrobin, orysastrobin,        picoxystrobin, pyraclostrobin, trifloxystrobin;    -   C4) a compound capable of to act as an uncoupler like dinocap,        fluazinam, meptyldinocap;    -   C5) a compound capable to inhibit ATP production like fentin        acetate, fentin chloride, fentin hydroxide, silthiofam;    -   C6) a compound capable to inhibit AA and protein biosynthesis        like andoprim, blasticidin-S, cyprodinil, kasugamycin,        kasugamycin hydrochloride hydrate, mepanipyrim, pyrimethanil;    -   C7) a compound capable to inhibit the signal transduction like        fenpiclonil, fludioxonil, quinoxyfen;    -   C8) a compound capable to inhibit lipid and membrane synthesis        like biphenyl, chlozolinate, edifenphos, etridiazole, iodocarb,        iprobenfos, iprodione, isoprothiolane, procymidone, propamocarb        or propamocarb-hydrochloride, pyrazophos, tolclofos-methyl,        vinclozolin;    -   C9) a compound capable to inhibit ergosterol biosynthesis like        aldimorph, azaconazole, bitertanol, bromuconazole,        cyproconazole, diclobutrazole, difenoconazole, diniconazole,        diniconazole-M, dodemorph, dodemorph acetate, epoxiconazole,        etaconazole, fenarimol, fenbuconazole, fenhexamid, fenpropidin,        fenpropimorph, fluquinconazole, flurprimidol, flusilazole,        flutriafol, furconazole, furconazole-cis, hexaconazole,        imazalil, imazalil sulfate, imibenconazole, ipconazole,        metconazole, myclobutanil, naftifine, nuarimol, oxpoconazole,        paclobutrazol, pefurazoate, penconazole, prochloraz,        propiconazole, prothioconazole, pyributicarb, pyrifenox,        simeconazole, spiroxamine, tebuconazole, terbinafine,        tetraconazole, triadimefon, triadimenol, tridemorph,        triflumizole, triforine, triticonazole, uniconazole,        viniconazole, voriconazole;    -   C10) a compound capable to inhibit cell wall synthesis like        benthiavalicarb, bialaphos, dimethomorph, flumorph,        iprovalicarb, mandipropamid, polyoxins, polyoxorim, validamycin        A;    -   C11) a compound capable to inhibit melanine biosynthesis like        carpropamid, diclocymet, fenoxanil, phthalide, pyroquilon,        tricyclazole;    -   C12) a compound capable to induce a host defence like        acibenzolar-S-methyl, probenazole, tiadinil;    -   C13) a compound capable to have a multisite action like Bordeaux        mixture, captafol, captan, chlorothalonil, copper naphthenate,        copper oxide, copper oxychloride, copper preparations such as        copper hydroxide, copper sulphate, dichlofluanid, dithianon,        dodine, dodine free base, ferbam, fluorofolpet, folpet,        guazatine, guazatine acetate, iminoctadine, iminoctadine        albesilate, iminoctadine triacetate, mancopper, mancozeb, maneb,        metiram, metiram zinc, oxine-copper, propineb, sulphur and        sulphur preparations including calcium polysulphide, thiram,        tolylfluanid, zineb, ziram;    -   C14) benthiazole, bethoxazin, capsimycin, carvone,        chinomethionat, cufraneb, cyflufenamid, cymoxanil, dazomet,        debacarb, dichlorophen, diclomezine, dicloran, difenzoquat,        difenzoquat methylsulphate, diphenylamine, ethaboxam, ferimzone,        flumetover, flusulfamide, fluopicolide, fluopyram also known as        N-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl}-2-(trifluoromethyl)benzamide,        fluoroimide, fosetyl-aluminium, fosetyl-calcium, fosetyl-sodium,        hexachlorobenzene, 8-hydroxyquinoline sulfate, irumamycin,        isotianil, methasulphocarb, metrafenone, methyl isothiocyanate,        mildiomycin, natamycin, nickel dimethyldithiocarbamate,        nitrothal-isopropyl, octhilinone, oxamocarb, oxyfenthiin,        pentachlorophenol and salts, 2-phenylphenol and salts,        phosphorous acid and its salts, piperalin, propanosine-sodium,        proquinazid, pyribencarb, pyrrolnitrine, quintozene,        tecloftalam, tecnazene, triazoxide, trichlamide, valiphenal,        zarilamid and 2,3,5,6-tetrachloro-4-(methylsulfonyl)-pyridine,        N-(4-chloro-2-nitrophenyl)-N-ethyl-4-methyl-benzenesulfonamide,        2-amino-4-methyl-N-phenyl-5-thiazolecarboxamide,        2-chloro-N-(2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl)-3-pyridincarboxamide,        3-[5-(4-chlorophenyl)-2,3-dimethylisoxazolidin-3-yl]pyridine,        cis-1-(4-chlorophenyl)-2-(1H-1,2,4-triazole-1-yl)-cycloheptanol,        methyl        1-(2,3-dihydro-2,2-dimethyl-1H-inden-1-yl)-1H-imidazole-5-carboxylate,        3,4,5-trichloro-2,6-pyridinedicarbonitrile,        methyl-2-[[[cyclopropyl[(4-methoxyphenyl)imino]methyl]thio]methyl]-.alpha.-(methoxymethylene)-benzeneacetate,        4-chloro-alpha-propynyloxy-N-[2-[3-methoxy-4-(2-propynyloxy)phenyl]ethyl]-benzeneacetamide,        (2S)—N-[2-[4-[[3-(4-chlorophenyl)-2-propynyl]oxy]-3-methoxyphenyl]ethyl]-3-methyl-2-[(methylsulfonyl)amino]-butanamide,        5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine,        5-chloro-6-(2,4,6-trifluorophenyl)-N-[(1R)-1,2,2-trimethylpropyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine,        5-chloro-N-[(1R)-1,2-dimethylpropyl]-6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine,        N-[1-(5-bromo-3-chloropyridin-2-yl)ethyl]-2,4-dichloronicotinamide,        N-(5-bromo-3-chloropyridin-2-yl)methyl-2,4-dichloronicotinamide,        2-butoxy-6-iodo-3-propyl-benzopyranon-4-one,        N-{(Z)-[(cyclopropylmethoxy)imino][6-(difluoromethoxy)-2,3-difluorophenyl]methyl}-2-phenylacetamide,        N-{2-[1,1′-bi(cyclopropyl)-2-yl]phenyl}-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide,        N-ethyl-N-methyl-N′-{2-methyl-5-(trifluoromethyl)-4-[3-(trimethylsilyl)propoxy]phenyl}imidoformamide,        N-ethyl-N-methyl-N′-{2-methyl-5-(difluoromethyl)-4-[3-(trimethylsilyl)propoxy]phenyl}imidoformamide,        N-(3-ethyl-3,5,5-trimethyl-cyclohexyl)-3-formylamino-2-hydroxy-benzamide,        N-(4-chlorobenzyl)-3-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]propanamide,        N-[(4-chlorophenyl)(cyano)methyl]-3-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]propanamide,        2-[[[[1-[3        (1Fluoro-2-phenylethyl)oxy]phenyl]ethylidene]amino]oxy]methyl]-alpha-(methoxyimino)-N-methyl-alphaE-benzeneacetamide,        N-(3′,4′-dichloro-5-fluorobiphenyl-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide,        2-(2-{[6-(3-chloro-2-methylphenoxy)-5-fluoropyrimidin-4-yl]oxy}phenyl)-2-(methoxyimino)-N-methylacetamide,        1-[(4-methoxyphenoxy)methyl]-2,2-dimethylpropyl-1H-imidazole-1-carboxylic        acid,        O-[1-[(4-methoxyphenoxy)methyl]-2,2-dimethylpropyl]-1H-imidazole-1-carbothioic        acid, a dipeptic mixture of        methyl-[S—(R,S)]-[3-(N-isopropoxycarbonylvalinyl)-amino]-3-(4-chloro-phenyl)propanoate,        methyl-(2-chloro-5-{(1E)-N-[(6-methylpyridin-2-yl)methoxy]-ethanimidoyl}benzyl)carbamate,        4-chloro-alpha-methoxy-N-[2-[3-methoxy-4-(2-propynyloxy)phenyl]ethyl]-benzeneacetamide,        3,4-dichloro-N-(2-cyanophenyl)isothiazole-5-carboxamide,        N-[2-(1,3-dimethyl-butyl)-phenyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide.

Most preferred compounds C in the composition according to the inventioncan be selected in the list consisting of benalaxyl, benalaxyl-M,benthiavalicarb, carboxin, chlorothalonil, cyazofamid, cymoxanil,dimetomorph, fluazinam, fludioxonil, fluoxastrobin, fluquinconazole,flutriafol, fosetyl-Al, hexaconazole, hymexazol, ipconazole, mancozeb,mandipropamid, maneb, mefenoxam, metalaxyl, metiram, penconazole,penthiopyrad, phosphorous acid, propamocarb-HCl, propineb,prothioconazole, tebuconazole, thiram, triadimenol, trifloxystrobin,triticonazole andN-[2-(1,3-dimethyl-butyl)-phenyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide.

The composition according to the invention preferably comprises

-   -   A) propamocarb-fosetylate;    -   B) an insecticide compound selected in the list consisting of        abamectin, aldicarb, beta-cyfluthrin, chlorpyrifos-E,        clothianidin, cyromazine, deltamethrin, diflubenzuron,        emamectin-benzoate, fipronil, gamma-cyhalothrin, imidacloprid,        L-cyhalothrin, methiocarb, pymetrozine, rynaxapyr, spinosad,        spirodiclofen, spiromesifen, spirotetramate, tebufenozide,        tebufenpyrad, tefluthrin, thiamethoxam, thiodicarb,        imidaclothiz,        (2E)-1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3,5-dimethyl-N-nitro-1,3,5-triazinan-2-imine        and    -   C) a further fungicide compound selected in the list consisting        of benalaxyl, benalaxyl-M, benthiavalicarb, carboxin,        chlorothalonil, cyazofamid, cymoxanil, dimetomorph, fluazinam,        fludioxonil, fluoxastrobin, fluquinconazole, flutriafol,        fosetyl-Al, hexaconazole, hymexazol, ipconazole, mancozeb,        mandipropamid, maneb, mefenoxam, metalaxyl, metiram,        penconazole, penthiopyrad, phosphorous acid, propamocarb-HCl,        propineb, prothioconazole, tebuconazole, thiram, triadimenol,        trifloxystrobin, triticonazole and        N-[2-(1,3-dimethyl-butyl)-phenyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide.

For the composition according to the invention the A/B/C weight ratiopreferably ranges from 1/100/100 to 1/0.01/0.01; more preferably from1/80/80 to 1/0.05/0.05; even more preferably from 1/50/100 to 1/1.5/2.5;still even more preferably from 1/12/25 to 1/6/12.

According to another aspect of the present invention, in the pesticidecomposition according to the invention, the compound ratio A/B/C can beadvantageously selected so as to produce a synergistic effect. The termsynergistic effect is understood to mean in particular that defined byColby in an article entitled “Calculation of the synergistic andantagonistic responses of herbicide combinations” Weeds, (1967), 15,pages 20-22.

The latter article mentions the formula:

$E = {X + Y + Z - \frac{XYZ}{100}}$

wherein E represents the expected percentage of inhibition of the pestfor the combination of the three compounds at defined doses (for exampleequal to x, y and z respectively), X is the percentage of inhibitionobserved for the pest by compound A at a defined dose (equal to x), Y isthe percentage of inhibition observed for the pest by compound B at adefined dose (equal to y) and Z is the percentage of inhibition observedfor the pest by compound C at a defined dose (equal to z). When thepercentage of inhibition observed for the combination is greater than E,there is a synergistic effect.

The term “synergistic effect” also means the effect defined byapplication of the Tammes method, “Isoboles, a graphic representation ofsynergism in pesticides”, Netherlands Journal of Plant Pathology, 70(1964), pages 73-80.

The pesticide composition according to the invention may comprise from0.00001 to 100%, preferably from 0.001 to 80%, of active compounds,whether these compounds are combined, or whether they are in the form oftwo or more active ingredients used separately.

More generally, the pesticide composition according to the invention mayeventually also comprise one or more other active substances selectedfrom fungicide, herbicide, insecticide or plant growth regulator activecompounds.

In addition to these additional active agents, the pesticide compositionaccording to the invention may also comprise any other adjuvants orauxiliary agent useful in plant protection formulations such as, forexample, an agriculturally suitable inert carrier and optionally anagriculturally suitable surfactant.

For its practical use, the pesticide composition according to theinvention can be used alone or in formulations containing one or theother of the active ingredients or alternatively both of them together,in combination or association with one or more other compatiblecomponents which are, for example, solid or liquid fillers or diluents,adjuvants, surfactants or equivalents, which are suitable for thedesired use and which are acceptable for uses in agriculture. Theformulations can be of any type known in the sector that is suitable forapplication onto all types of cultures or crops. These formulations,which can be prepared in any manner known by the skilled person, alsoform part of the invention.

The formulations may also contain ingredients of other types, such asprotective colloids, adhesives, thickeners, thixotropic agents,penetrating agents, oils for spraying, stabilisers, preserving agents(in particular mould-proofing or biocide agents), sequestering orchelating agents or the like. More generally, the compounds used in theinvention can be combined with any solid or liquid additivescorresponding to the usual formulation techniques.

The term “filler” means an organic or inorganic, natural or syntheticcomponent with which the active components are combined to facilitateits application, for example, onto the plants, the seeds or the soil.This filler is consequently generally inert and it must be acceptable(for example acceptable for agronomic uses, in particular for treatingplants).

The filler can be solid, for example clays, natural or syntheticsilicates, silica, resins, waxes, solid fertilizers (for exampleammonium salts), natural soil minerals, such as kaolins, clays, talc,lime, quartz, attapulgite, montmorillonite, bentonite or diatomaceousearths, or synthetic minerals, such as silica, alumina or silicates, inparticular aluminium or magnesium silicates. The solid fillers which aresuitable for granules are as follows: natural, crushed or broken rocks,such as calcite, marble, pumice, sepiolite and dolomite; syntheticgranules of inorganic or organic flours; granules of organic materialsuch as sawdust, coconut shell, corn ear or envelope, or tobacco stem;kieselguhr, tricalcium phosphate, powdered cork or adsorbent carbonblack; water-soluble polymers, resins, waxes; or solid fertilizers. Suchcomposition may, if so desired, contain one or more compatible agentssuch as wetting agents, dispersing agents, emulsifiers or colouringswhich, when they are solid, may also act as diluents.

The fillers may also be liquid, for example: water, alcohols, inparticular butanol or glycol, as well as ethers or esters thereof, inparticular methyl glycol acetate; ketones, in particular acetone,cyclohexanone, methyl ethyl ketone, methyl isobutyl ketone orisophorone; petroleum fractions such as paraffinic or aromatichydrocarbons, in particular xylenes or alkylnaphthalenes; mineral orplant oils; aliphatic chlorohydrocarbons, in particular trichloroethaneor methylene chloride; aromatic chlorohydrocarbons, in particularchlorobenzenes; water-soluble or highly polar solvents such asdimethylformamide, dimethyl sulphoxide, N,N-dimethyl-acetamide orN-methylpyrrolidone; N-octylpyrrolidone, liquefied gases; or the like,whether they are taken separately or as a mixture.

The surfactant can be an emulsifier, a dispersing agent or a wettingagent, of ionic or nonionic type or a mixture of these surfactants.Among those surfactants there are used, for example, polyacrylic acidsalts, lignosulphonic acid salts, phenolsulphonic ornaphthalenesulphonic acid salts, polycondensates of ethylene oxide withfatty alcohols or fatty acids or fatty esters or fatty amines,substituted phenols (in particular alkylphenols or arylphenols),ester-salts of sulphosuccinic acid, taurine derivatives (in particularalkyl taurates), phosphoric esters of alcohols or of polycondensates ofethylene oxide with phenols, fatty acid esters with polyols, orsulphate, sulphonate or phosphate functional derivatives of thecompounds described above. The presence of at least one surfactant isgenerally essential when the active ingredients and/or the inert fillerare insoluble or only sparingly soluble in water and when the filler forthe said composition to be applied is water.

The formulations may also contain other additives such as adhesives ordyes. Adhesives such as carboxymethylcellulose or natural or syntheticpolymers in the form of powders, granules or matrices, such as gumarabic, latex, polyvinylpyrrolidone, polyvinyl alcohol or polyvinylacetate, natural phospholipids, such as cephalins or lecithins, orsynthetic phospholipids can be used in the formulations. It is possibleto use colourings such as inorganic pigments, such as, for example: ironoxides, titanium oxides, Prussian blue; organic colouring stuffs, suchas those of the alizarin, azo or metal phthalocyanin type; or of traceelements such as iron, manganese, boron, copper, cobalt, molybdenum orzinc salts.

The form of the pesticide composition according to the invention can beselected in a large number of formulations, such as aerosol dispenser;suspension of capsules; cold fogging concentrate; dustable powder;emulsifiable concentrate; aqueous/aqueous type emulsion; oil/inversetype emulsion; encapsulated granule; fine granule; suspensionconcentrate for seed treatment; compressed gas; gas generating product;granule; hot fogging concentrate; macrogranule; microgranule;oil-dispersible powder; oil miscible suspension concentrate;oil-miscible liquid; paste; plant rodlet; powder for dry seed treatment;seeds coated with a pesticide; smoke maydle; smoke cartridge; smokegenerator; smoke pellet; smoke rodlet; smoke tablet; smoke tin; solubleconcentrate; soluble powder; solution for seed treatment; suspensionconcentrate (=flowable concentrate); ultra low volume liquid; ultra lowvolume suspension; vapour releasing product; water-dispersible granulesor tablets; water dispersible powder for slurry treatment; water-solublegranules or tablets; water-soluble powder for seed treatment; wettablepowder.

The pesticide composition according to the present invention covers notonly the compositions which are ready to be applied to the crop by meansof a suitable device, such as a spraying device, but also the commercialconcentrated composition which have to be diluted before application tothe crop.

The pesticide composition herein described is used in general forapplication to growing plants, or to sites where crops are grown orintended to grow, or for the treatment, coating or film-coating ofseeds.

According to the present invention, seeds may comprise any propagationmaterials, like for example seeds, fruit, tubers, grains, roots,rhizomes, parts of plants.

The pesticide composition according to the invention may also be appliedto the vegetation and in particular to the leaves infested or capable ofbeing infested with the phytopathogenic fungi or damaged by insects.Another method of applying the pesticide composition according to theinvention is to add a formulation containing the active ingredients tothe irrigation water.

According to another object of the present invention, there is provideda method for controlling the phytopathogenic fungi or damaging insectsof plants, crops or seeds, characterized in that an agronomicallyeffective and substantially non-phytotoxic quantity of a pesticidecomposition according to the invention is applied as seed treatment,foliar application, stem application, drench or drip application orchemigation to the seed, the plant or to the fruit of the plant or tosoil or to inert substrate (e.g. inorganic substrates like sand,rockwool, glasswool; expanded minerals like perlite, vermiculite,zeolite or expanded clay), Pumice, Pyroclastic materials or stuff,synthetic organic substrates (e.g. polyurethane), organic substrates(e.g. peat, composts, tree waste products like coir, wood fibre orchips, tree bark) or to a liquid substrate (e.g. floating hydroponicsystems, Nutrient Film Technique, Aeroponics) wherein the plant isgrowing or in which it is desired to grow.

The expression “are applied to the plants to be treated” is understoodto mean, for the purposes of the present invention, that the pesticidecomposition which is the subject of the invention can be applied bymeans of various methods of treatment such as:

-   -   spraying onto the aerial parts of the said plants a liquid        comprising one of the said compositions,    -   dusting, the incorporation into the soil of granules or powders,        spraying, around the said plants, and in the case of trees        injection or daubing,    -   coating or film-coating the seeds of the said plants with the        aid of a plant-protection mixture comprising one of the said        compositions.

The method according to the invention may either be a curing, preventingor eradicating method. In this method, a composition used can beprepared beforehand by mixing the two or more active compounds accordingto the invention.

According to an alternative of such a method, it is also possible toapply simultaneously, successively or separately compounds (A) and (B)and optionally (C) so as to have the conjugated (A)/(B) (optionally (C))effects, of distinct compositions each containing one of the two orthree active ingredients (A) or (B), optionally (C). Such a method canbe extended to the further application of compound (C).

The dose of active compound usually applied in the method of treatmentaccording to the invention is generally and advantageously

-   -   for foliar treatments: from 0.1 to 10,000 g/ha, preferably from        10 to 1,000 g/ha, more preferably from 50 to 300 g/ha; in case        of drench or drip application, the dose can even be reduced,        especially while using inert substrates like rockwool or        perlite;    -   for seed treatment: from 2 to 200 g per 100 kilogram of seed,        preferably from 3 to 150 g per 100 kilogram of seed;    -   for soil treatment: from 0.1 to 10,000 g/ha, preferably from 1        to 5,000 g/ha.

The doses herein indicated are given as illustrative examples of themethod according to the invention. A person skilled in the art will knowhow to adapt the application doses, notably according to the nature ofthe plant or crop to be treated.

Under specific conditions, for example according to the nature of thephytopathogenic fungus to be treated or insect to control, a lower dosemay offer adequate protection. Certain climatic conditions, resistanceor other factors like the nature of the phytopathogenic fungi ordamaging insect to be eliminated or the degree of infestation, forexample, of the plants with these fungi, may require higher doses ofcombined active ingredients.

The optimum dose usually depends on several factors, for example on thetype of phytopathogenic fungus to be treated or insect to control, onthe type or level of development of the infested plant, on the densityof vegetation, or alternatively on the method of application.

Without it being limiting, the crop treated with the pesticidecomposition or combination according to the invention is, for example,grapevine, but this could be cereals, vegetables, lucerne, soybean,market garden crops, turf, wood, tree or horticultural plants.

The method of treatment according to the invention may also be useful totreat propagation material such as tubers or rhizomes, but also seeds,seedlings or seedlings pricking out and plants or plants pricking out.This method of treatment may also be useful to treat roots. The methodof treatment according to the invention may also be useful to treat theover-ground parts of the plant such as trunks, stems or stalks, leaves,flowers and fruit of the concerned plant.

Among the plants that can be protected by the method according to theinvention, mention can be made of cotton; flax; vine; fruit or vegetablecrops such as Rosaceae sp. (for instance pip fruit such as apples andpears, but also stone fruit such as apricots, almonds and peaches),Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp.,Fagaceae sp., Moraceae sp., Oleaceae sp., Actimidaceae sp., Lauraceaesp., Musaceae sp. (for instance banana trees and plantins), Rubiaceaesp., Theaceae sp., Sterculiceae sp., Rutaceae sp. (for instance lemons,oranges and grapefruit); Solanaceae sp. (for instance tomatoes),Liliaceae sp., Asteraceae sp. (for instance lettuces), Umbelliferae sp.,Cruciferae sp., Chenopodiaceae sp., Cucurbitaceae sp., Papilionaceae sp.(for instance peas), Rosaceae sp. (for instance strawberries); majorcrops such as Graminae sp. (for instance maize, lawn or cereals such aswheat, rice, barley and triticale), Asteraceae sp. (for instancesunflower), Cruciferae sp. (for instance colza), Fabacae sp. (forinstance peanuts), Papilionaceae sp. (for instance soybean), Solanaceaesp. (for instance potatoes), Chenopodiaceae sp. (for instancebeetroots); horticultural and forest crops; as well as geneticallymodified homologues of these crops.

The composition according to the invention may also be used in thetreatment of genetically modified organisms with the compounds accordingto the invention or the agrochemical compositions according to theinvention. Genetically modified plants are plants into genome of which aheterologous gene encoding a protein of interest has been stablyintegrated. The expression “heterologous gene encoding a protein ofinterest” essentially means genes which give the transformed plant newagronomic properties, or genes for improving the agronomic quality ofthe modified plant.

The composition according to the invention may also be used againstfungal diseases liable to grow on or inside timber. The term “timber”means all types of species of wood, and all types of working of thiswood intended for construction, for example solid wood, high-densitywood, laminated wood, and plywood. The method for treating timberaccording to the invention mainly consists in contacting one or morecompounds according to the invention, or a composition according to theinvention; this includes for example direct application, spraying,dipping, injection or any other suitable means.

Among the diseases of plants or crops that can be controlled by themethod according to the invention, mention can be made of:

Powdery mildew diseases such as:

-   -   Blumeria diseases, caused for example by Blumeria graminis;    -   Podosphaera diseases, caused for example by Podosphaera        leucotricha;    -   Sphaerotheca diseases, caused for example by Sphaerotheca        fuliginea;    -   Uncinula diseases, caused for example by Uncinula necator ;        Rust diseases such as:    -   Gymnosporangium diseases, caused for example by Gymnosporangium        sabinae;    -   Hemileia diseases, caused for example by Hemileia vastatrix ;    -   Phakopsora diseases, caused for example by Phakopsora pachyrhizi        or Phakopsora meibomiae;    -   Puccinia diseases, caused for example by Puccinia recondite;    -   Uromyces diseases, caused for example by Uromyces        appendiculatus;        Oomycete diseases such as:    -   Bremia diseases, caused for example by Bremia lactucae;    -   Peronospora diseases, caused for example by Peronospora pisi        or P. brassicae;    -   Phytophthora diseases, caused for example by Phytophthora        infestans;    -   Plasmopara diseases, caused for example by Plasmopara viticola;    -   Pseudoperonospora diseases, caused for example by        Pseudoperonospora humuli or Pseudoperonospora cubensis;    -   Pythium diseases, caused for example by Pythium ultimum ;        Leafspot, leaf blotch and leaf blight diseases such as:    -   Alternaria diseases, caused for example by Alternaria solani;    -   Cercospora diseases, caused for example by Cercospora beticola ;    -   Cladiosporum diseases, caused for example by Cladiosporium        cucumerinum;    -   Cochliobolus diseases, caused for example by Cochliobolus        sativus;    -   Colletotrichum diseases, caused for example by Colletotrichum        lindemuthanium;    -   Cycloconium diseases, caused for example by Cycloconium        oleaginum;    -   Diaporthe diseases, caused for example by Diaporthe citri;    -   Elsinoe diseases, caused for example by Elsinoe fawcettii;    -   Gloeosporium diseases, caused for example by Gloeosporium        laeticolor;    -   Glomerella diseases, caused for example by Glomerella cingulata;    -   Guignardia diseases, caused for example by Guignardia bidwelli;    -   Leptosphaeria diseases, caused for example by Leptosphaeria        maculans; Leptosphaeria nodorum;    -   Magnaporthe diseases, caused for example by Magnaporthe grisea;    -   Mycosphaerella diseases, caused for example by Mycosphaerella        graminicola; Mycosphaerella arachidicola; Mycosphaerella        Riensis;    -   Phaeosphaeria diseases, caused for example by Phaeosphaeria        nodorum;    -   Pyrenophora diseases, caused for example by Pyrenophora teres;    -   Ramularia diseases, caused for example by Ramularia collo-cygni;    -   Rhynchosporium diseases, caused for example by Rhynchosporium        secalis;    -   Septoria diseases, caused for example by Septoria apii or        Septoria lycopercisi;    -   Typhula diseases, caused for example by Typhula incarnate;    -   Venturia diseases, caused for example by Venturia inaequalis ;        Root and stem diseases such as:    -   Corticium diseases, caused for example by Corticium graminearum;    -   Fusarium diseases, caused for example by Fusarium oxysporum;    -   Gaeumannomyces diseases, caused for example by Gaeumannomyces        graminis;    -   Rhizoctonia diseases, caused for example by Rhizoctonia solani ;    -   Tapesia diseases, caused for example by Tapesia acuformis;    -   Thielaviopsis diseases, caused for example by Thielaviopsis        basicola;        Ear and panicle diseases such as:    -   Alternaria diseases, caused for example by Alternaria spp.;    -   Aspergillus diseases, caused for example by Aspergillus flavus;    -   Cladosporium diseases, caused for example by Cladosporium spp.;    -   Claviceps diseases, caused for example by Claviceps purpurea;    -   Fusarium diseases, caused for example by Fusarium culmorum;    -   Gibberella diseases, caused for example by Gibberella zeae;    -   Monographella diseases, caused for example by Monographella        nivalis ;        Smut and bunt diseases such as:    -   Sphacelotheca diseases, caused for example by Sphacelotheca        reiliana;    -   Tilletia diseases, caused for example by Tilletia caries;    -   Urocystis diseases, caused for example by Urocystis occulta;    -   Ustilago diseases, caused for example by Ustilago nuda ;        Fruit rot and mould diseases such as:    -   Aspergillus diseases, caused for example by Aspergillus flavus;    -   Botrytis diseases, caused for example by Botrytis cinerea;    -   Penicillium diseases, caused for example by Penicillium        expansum;    -   Sclerotinia diseases, caused for example by Sclerotinia        sclerotiorum ;    -   Verticilium diseases, caused for example by Verticilium        alboatrum;        Seed and soilborne decay, mould, wilt, rot and damping-off        diseases:    -   Fusarium diseases, caused for example by Fusarium culmorum;    -   Phytophthora diseases, caused for example by Phytophthora        cactorum;    -   Pythium diseases, caused for example by Pythium ultimum;    -   Rhizoctonia diseases, caused for example by Rhizoctonia solani ;    -   Sclerotium diseases, caused for example by Sclerotium rolfsii;    -   Microdochium diseases, caused for example by Microdochium nivale        ;        Canker, broom and dieback diseases such as:    -   Nectria diseases, caused for example by Nectria galligena;        Blight diseases such as:    -   Monilinia diseases, caused for example by Monilinia laxa;        Leaf blister or leaf curl diseases such as:    -   Taphrina diseases, caused for example by Taphrina deformans;        Decline diseases of wooden plants such as:    -   Esca diseases, caused for example by Phaemoniella clamydospora;    -   Eutypa dyeback, caused for example by Eutypa lata;    -   Dutch elm disease, caused for example by Ceratocystsc ulmi;        Diseases of flowers and Seeds such as:    -   Botrytis diseases, caused for example by Botrytis cinerea ;        Diseases of tubers such as:    -   Rhizoctonia diseases, caused for example by Rhizoctonia solani    -   Helminthosporium diseases, caused for example by        Helminthosporium solani.

The damaging insects of crops which can be controlled at any developmentstage by using the pesticide composition according to the inventioninclude:

-   -   pests from the order of Isopoda for example Oniscus asellus,        Armadillidium vulgare, Porcellio scaber;    -   pests from the order of Diplopoda for example Blaniulus        guttulatus;    -   pests from the order of Chilopoda for example Geophilus        carpophagus, Scutigera spp.;    -   pests from the order of Symphyla for example Scutigerella        immaculata;    -   pests from the order of Thysanura for example Lepisma        saccharina;    -   pests from the order of Collembola for example Onychiurus        armatus;    -   pests from the order of Orthoptera for example Acheta        domesticus, Gryllotalpa spp., Locusta migratoria migratorioides,        Melanoplus spp., Schistocerca gregaria;    -   pests from the order of Blattaria for example Blatta orientalis,        Periplaneta americana, Leucophaea maderae, Blattella germanica;    -   pests from the order of Dermaptera for example Forficula        auricularia;    -   pests from the order of Isoptera for example Reticulitermes        spp.;    -   pests from the order of Phthiraptera for example Pediculus        humanus corporis, Haematopinus spp., Linognathus spp.,        Trichodectes spp., Damalinia spp.;    -   pests from the order of Thysanoptera for example Hercinothrips        femoralis, Thrips tabaci, Thrips palmi, Frankliniella        accidentalis;    -   pests from the order of Heteroptera for example Eurygaster spp.,        Dysdercus intermedius, Piesma quadrata, Cimex lectularius,        Rhodnius prolixus, Triatoma spp;    -   pests from the order of Homoptera for example Aleurodes        brassicae, Bemisia tabaci, Trialeurodes vaporariorum, Aphis        gossypii, Brevicoryne brassicae, Cryptomyzus ribis, Aphis fabae,        Aphis pomi, Eriosoma lanigerum, Hyalopterus arundinis,        Phylloxera vastatrix, Pemphigus spp., Macrosiphum avenae, Myzus        spp., Phorodon humuli, Rhopa-losiphum padi, Empoasca spp.,        Euscelis bilobatus, Nephotettix cincticeps, Lecanium corni,        Saissetia oleae, Laodelphax striatellus, Nilaparvata lugens,        Aonidiella aurantii, Aspidiotus hederae, Pseudococcus spp.,        Psylla spp;    -   pests from the order of Lepidoptera for example Pectinophora        gossypiella, Bupalus piniarius, Chematobia brumata,        Lithocolletis blancardella, Hyponomeuta padella, Plutella        xylostella, Malacosoma neustria, Euproctis chrysorrhoea,        Lymantria spp., Bucculatrix thurberiella, Phyllocnistis        citrella, Agrotis spp., Euxoa spp., Feltia spp., Earias        insulana, Heliothis spp., Mamestra brassicae, Panolis flammea,        Spodoptera spp., Trichoplusia ni, Carpocapsa pomonella, Pieris        spp., Chilo spp., Pyrausta nubilalis, Ephestia kuehniella,        Galleria mellonella, Tineola bisselliella, Tinea pellionella,        Hofmannophila pseudospretella, Cacoecia podana, Capua        reticulana, Choristoneura fumiferana, Clysia ambiguella, Homona        magnanima, Tortrix viridana, Cnaphalocerus spp., Oulema oryzae;    -   pests from the order of Coleoptera for example Anobium        punctatum, Rhizopertha dominica, Bruchidius obtectus,        Acanthoscelides obtectus, Hylotrupes bajulus, Agelastica alni,        Leptinotarsa decemlineata, Phaedon cochleariae, Diabrotica spp.,        Psylliodes chrysocephala, Epilachna varivestis, Atomaria spp.,        Oryzaephilus surinamensis, Anthonomus spp., Sitophilus spp.,        Otiorrhynchus sulcatus, Cosmopolites sordidus, Ceuthorrhynchus        assimilis, Hypera postica, Dermestes spp., Trogoderma spp.,        Anthrenus spp., Attagenus spp., Lyctus spp., Meligethes aeneus,        Ptinus spp., Niptus hololeucus, Gibbium psylloides, Tribolium        spp., Tenebrio molitor, Agriotes spp., Conoderus spp.,        Melolontha melolontha, Amphimallon solstitialis, Costelytra        zealandica, Lissorhoptrus oryzophilus;    -   pests from the order of Hymenoptera for example Diprion spp.,        Hoplocampa spp., Lasius spp., Monomorium pharaonis, Vespa spp;    -   pests from the order of Diptera for example Aedes spp.,        Anopheles spp., Culex spp., Drosophila melanogaster, Musca spp.,        Fannia spp., Calliphora erythrocephala, Lucilia spp., Chrysomyia        spp., Cuterebra spp., Gastrophilus spp., Hyppobosca spp.,        Stomoxys spp., Oestrus spp., Hypoderma spp., Tabanus spp.,        Tannia spp., Bibio hortulanus, Oscinella frit, Phorbia spp.,        Pegomyia hyoscyami, Ceratitis capitata, Dacus oleae, Tipula        paludosa, Hylemyia spp., Liriomyza spp.;    -   pests from the order of Siphonaptera for example Xenopsylla        cheopis, Ceratophyllus spp.;    -   pests from the class of Arachnida for example Scorpio maurus,        Latrodectus mactans, Acarus siro, Argas spp., Ornithodoros spp.,        Dermanyssus gallinae, Eriophyes ribis, Phyllocoptruta oleivora,        Boophilus spp., Rhipicephalus spp., Amblyomma spp., Hyalomma        spp., Ixodes spp., Psoroptes spp., Chorioptes spp., Sarcoptes        spp., Tarsonemus spp., Bryobia praetiosa, Panonychus spp.,        Tetranychus spp., Hemitarsonemus spp., Brevipalpus spp;    -   the plant-parasitic neamnotes such as Pratylenchus spp.,        Radopholus similis, Ditylenchus dipsaci, Tylenchulus        semipenetrans, Heterodera spp., Globodera spp., Meloidogyne        spp., Aphelenchoides spp., Longidorus spp., Xiphinema spp.,        Trichodorus spp., Bursaphelenchus spp.

As a further aspect, the present invention provides a product comprisinga compound (A) and a compound (B) and optionally a compound (C), asherein defined, as a combined preparation for simultaneous, separate orsequential use in controlling the phytopathogenic fungi or damaginginsects of plants, crops or seeds at a site.

The pesticide composition according to the invention can be preparedimmediately before use by using a kit-of-parts for controlling,curatively or preventively, the phytopathogenic fungi of crops, such akit-of-parts may comprise at least one compound (A) and at least onecompound (B) and optionally compound (C) intended to be combined or usedsimultaneously, separately or sequentially in controlling thephytopathogenic fungi of crops at a site.

It is therefore a pack in which the user finds all the ingredients forpreparing the fungicide formulation which they wish to apply to thecrops. These ingredients, which comprise in particular the active agents(A) and (B) and optionally compound (C) and which are packagedseparately, are provided in the form of a powder or in the form of aliquid which is concentrated to a greater or lesser degree. The usersimply has to mix in the prescribed doses and to add the quantities ofliquid, for example of water, necessary to obtain a formulation which isready to use and which can be applied to the crops.

The present invention can be illustrated by the following andnon-limitative examples.

Efficacy Example A Myzus persicae Test

Solvent: 7 parts by weight of dimethylformamide Emulsifier: 2 parts byweight of alkylaryl polyglycolether

To produce a suitable preparation of active compound, 1 part by weightof active compound is mixed with the stated amount of solvent andemulsifier, and the concentrate is diluted with emulsifier-containingwater to the desired concentration.

Cabbage leaves (Brassica oleracea) which are heavily infested by thegreen peach aphid (Myzus persicae) are treated by being dipped into thepreparation of the active compound at the desired concentration.

After a period of time of 6 days, the mortality is determined. 100%means that all the aphids have been killed; 0% means that none of theaphids have been killed.

According to the present application in this test e.g. the followingcombination shows a synergistic effect in comparison to the singlecompounds. The results are presented in table 1.

TABLE 1 Rate of Expected value application of according to activeEfficacy Colby formula compound (ppm) (%) (%) Propamocarb-fosetylate 2000 / Clothianidin 0.8 75 / Propamocarb-fosetylate + 200 + 0.8 95 81Clothianidin

Efficacy Example B Phaedon cochleariae Test

Solvent: 7 parts by weight of dimethylformamide Emulsifier: 2 parts byweight of alkylaryl polyglycolether

To produce a suitable preparation of active compound, 1 part by weightof active compound is mixed with the stated amount of solvent andemulsifier, and the concentrate is diluted with emulsifier-containingwater to the desired concentration.

Cabbage leaves (Brassica oleracea) are treated by being dipped into thepreparation of the active compound at the desired concentration and areinfested with larvae of the mustard beetle Phaedon cochleariae as longas the leaves are still moist.

After a period of time of 4 days, the mortality is determined. 100%means that all the aphids have been killed; 0% means that none of theaphids have been killed.

According to the present application in this test e.g. the followingcombination shows a synergistic effect in comparison to the singlecompounds. The results are presented in table 2.

TABLE 2 Rate of Expected value application of according to activeEfficacy Colby formula compound (ppm) (%) (%) Propamocarb-fosetylate 2005 / Imidacloprid  20 80 / Propamocarb-fosetylate + 200 + 20 100 81Imidacloprid

Efficacy Example C Plutella xylostella Test

Solvent: 7 parts by weight of dimethylformamide Emulsifier: 2 parts byweight of alkylaryl polyglycolether

To produce a suitable preparation of active compound, 1 part by weightof active compound is mixed with the stated amount of solvent andemulsifier, and the concentrate is diluted with emulsifier-containingwater to the desired concentration.

Cabbage leaves (Brassica oleracea) are treated by being dipped into thepreparation of the active compound at the desired concentration and areinfested with larvae of the diamond black moth Plutella xylostella aslong as the leaves are still moist.

After a period of time of 6 days, the mortality is determined. 100%means that all the caterpillars have been killed; 0% means that none ofthe caterpillars have been killed.

According to the present application in this test e.g. the followingcombination shows a synergistic effect in comparison to the singlecompounds. The results are presented in table 3.

TABLE 3 Rate of Expected value application of according to activeEfficacy Colby formula compound (ppm) (%) (%) Propamocarb-fosetylate 2000 / thiacloprid  20 20 / Propamocarb-fosetylate + 200 + 20 65 20thiacloprid

1. A composition comprising: A) propamocarb-fosetylate and B) aninsecticide compound selected from the group consisting of abamectin,acephate, acetamiprid, acrinathrin, aldicarb, alpha-cypermethrin,beta-cyfluthrin, bifenthrin, carbaryl, carbofuran, chlorfenapyr,chlorfluazuron, chlorpyrifos-E, cyfluthrin, cypermethrin, cyromazine,deltamethrin, diflubenzuron, dinotefuran, emamectin-benzoate, ethiprole,fenpyroximate, fipronil, flonicamid, flubendiamide, flufenoxuron,gamma-cyhalothrin, hexaflumuron, indoxacarb, L-cyhalothrin, lepimectin,lufenuron, methamidophos, methiocarb, methomyl, methoxyfenozide,milbemycin, nitenpyram, novaluron, profenofos, pymetrozine, rynaxapyr,spinosad, spirodiclofen, spiromesifen, spirotetramate, tebufenozide,tebufenozide, tebufenpyrad, tebufenpyrad, tebupirimphos, teflubenzuron,tefluthrin, thiamethoxam, thiodicarb, triazophos triflumuron,imidaclothiz, and(2E)-1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3,5-dimethyl-N-nitro-1,3,5-triazinan-2-imine;wherein components A) and B) are in an A/B weight ratio ranging from1/1,000 to 1,000/1.
 2. A composition according to claim 1, whereincompound B is selected from the group consisting of abamectin,acetamiprid, aldicarb, beta-cyfluthrin, carbofuran, chlorpyrifos-E,cypermethrin, cyromazine, deltamethrin, diflubenzuron,emamectin-benzoate, ethiprole, fipronil, gamma-cyhalothrin,L-cyhalothrin, lufenuron, methiocarb, methoxyfenozide, pymetrozine,rynaxapyr, spinosad, spirodiclofen, spiromesifen, spirotetramate,tebufenozide, tebufenpyrad, tefluthrin, thiamethoxam, thiodicarb,triflumuron, imidaclothiz and(2E)-1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3,5-dimethyl-N-nitro-1,3,5-triazinan-2-imine.3. A composition according to claim 1, wherein compound B is selectedfrom the group consisting of abamectin, aldicarb, beta-cyfluthrin,chlorpyrifos-E, cyromazine, deltamethrin, diflubenzuron,emamectin-benzoate, fipronil, gamma-cyhalothrin, L-cyhalothrin,methiocarb, pymetrozine, rynaxapyr, spinosad, spirodiclofen,spiromesifen, spirotetramate, tebufenozide, tebufenpyrad, tefluthrin,thiamethoxam, thiodicarb, imidaclothiz,(2E)-1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3,5-dimethyl-N-nitro-1,3,5-triazinan-2-imine.4. A composition according to claim 1, wherein the A/B weight ratioranges from 1/125 to 125/1.
 5. A composition according to claim 1,wherein the A/B weight ratio ranges from 1/25 to 25/1.
 6. A compositionaccording to claim 1, further comprising C) a further fungicide compoundin an A/B/C weight ratio ranging from 1/1,000/1,000 to 1/0.001/0.001. 7.A composition according to claim 6, wherein compound C is selected fromthe group consisting of benalaxyl, benalaxyl-M, benthiavalicarb,carboxin, chlorothalonil, cyazofamid, cymoxanil, dimetomorph, fluazinam,fludioxonil, fluoxastrobin, fluquinconazole, flutriafol, fosetyl-Al,hexaconazole, hymexazol, ipconazole, mancozeb, mandipropamid, maneb,mefenoxam, metalaxyl, metiram, penconazole, penthiopyrad, phosphorousacid, propamocarb-HCl, propineb, prothioconazole, tebuconazole, thiram,triadimenol, trifloxystrobin, triticonazole andN-[2-(1,3-dimethyl-butyl)-phenyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide.8. A composition according to claim 6, wherein the A/B/C weight ratioranges from 1/100/100 to 1/0.01/0.01.
 9. A composition according toclaim 6, wherein the A/B/C weight ratio ranges from 1/80/80 to1/0.05/0.05
 10. A composition according to claim 6, wherein the A/B/Cweight ratio ranges from 1/50/100 to 1/1.5/2.5.
 11. A compositionaccording to claim 6, wherein the A/B/C weight ratio ranges from 1/12/25to 1/6/12.
 12. A method for controlling phytopathogenic fungi ordamaging insects of plants, crops, or seeds, comprising: (a) applying anagronomically effective and substantially non-phytotoxic quantity of acomposition according to claim 1 to: a seed, a plant, fruit of a plant,soil, or to a substrate wherein a plant is growing or in which a plantis desired to grow.
 13. A method according to claim 12, wherein saidapplying of step (a) occurs through foliar application, stemapplication, drench application, drip application, or chemigation.
 14. Amethod for controlling phytopathogenic fungi or damaging insects ofplants, crops, or seeds, comprising: (a) applying an agronomicallyeffective and substantially non-phytotoxic quantity of a pesticidecomposition to: a seed, a plant, fruit of a plant, soil, or to asubstrate wherein a plant is growing or in which a plant is desired togrow, wherein said pesticide composition from step (a) comprises: A)propamocarb-fosetylate and B) an insecticide compound selected from thegroup consisting of clothianidin, imidacloprid, and thiacloprid; whereincomponents A) and B) are in an A/B weight ratio ranging from 1/1,000 to1,000/1.